Francis Donders and the Birth of Mental Chronometry
In 1868, Dutch physiologist Franciscus Donders pioneered the technique of mental chronometry—measuring the speed of cognitive processing to infer the architecture of the human mind. Prior to Donders, scientists believed mental thought was instantaneous and immaterial. Donders demonstrated that decision-making requires physical time by isolating distinct cognitive stages using his famous Subtraction Method.
By comparing three experimental paradigms—Simple Reaction Time (Type A), Choice Reaction Time (Type B), and Go/No-Go Reaction Time (Type C)—Donders proved that human reaction time is composite: basic sensory-motor transmission + stimulus discrimination + response selection.
The Three Classical Reaction Time Paradigms
1. Simple Reaction Time (Donders A-Reaction): A single known stimulus requires a single pre-specified response (e.g. clicking when a box turns green). The motor command can be pre-loaded into the premotor cortex, requiring only an execution trigger. Average latency: 215–250ms.
2. Go/No-Go Reaction Time (Donders C-Reaction): Two or more stimuli may appear, but the subject must respond only to one target stimulus while withholding response to distractors (e.g. click for green, do not click for red). This introduces Stimulus Discrimination: the visual cortex and inferior temporal lobe must categorize the signal before the motor cortex can fire. Average latency: 290–330ms (+75ms cost).
3. Choice Reaction Time (Donders B-Reaction): Multiple stimuli are mapped to multiple distinct motor responses (e.g. red = left click, blue = right click, yellow = spacebar). This requires both Stimulus Discrimination AND Response Selection. Average latency for 2 choices: 320–360ms; for 4 choices: 420–480ms.

Neural Circuitry: The Frontoparietal-Striatal Loop
Why does choice take so long? In simple reaction tasks, motor preparation is completed prior to the stimulus. When multiple choices are possible, the brain cannot fully prepare any single motor tract without risking error. Instead, competing motor plans are held in a state of mutual inhibition within the Dorsolateral Prefrontal Cortex (DLPFC) and Supplementary Eye Fields (SEF).
Once the stimulus is discriminated, the striatum (caudate nucleus and putamen) must disinhibit the selected motor pathway through the basal ganglia direct pathway while suppressing all alternative options via the indirect and hyperdirect pathways. This internal neural arbitration loop adds 100ms to 250ms of computational latency.
Hick-Hyman Law and Information Entropy
Choice reaction time does not increase linearly with the number of choices; it scales logarithmically according to Hick's Law (Hick, 1952; Hyman, 1953): RT = a + b * log2(n + 1), where n is the number of equiprobable choices and log2(n + 1) represents information entropy in bits.
This logarithmic relationship reveals that the human brain resolves complex decisions through hierarchical binary elimination rather than serial checking. Going from 1 option to 2 options adds ~100ms; going from 2 to 4 options adds another ~100ms; but going from 4 to 8 options still only adds ~100ms.
Tactical Applications in Esports, Driving, and Athletics
In competitive environments, elite performers survive by artificially converting Choice RT scenarios into Simple RT scenarios. In first-person shooters (FPS), professional players pre-aim common corner angles: by anticipating exactly where an enemy will appear, they eliminate stimulus discrimination and response selection, dropping their engagement latency from ~400ms down to ~180ms.
Similarly, defensive driving programs train drivers to maintain buffer zones: unexpected obstacles force high-entropy Choice RT (brake vs. swerve left vs. swerve right), leading to fatal 600ms+ decision delays compared to pre-planned single-action braking.
- Donders’ Subtraction Method demonstrated that mental decision-making consists of discrete, measurable neural stages.
- Stimulus discrimination (Go/No-Go) adds ~75–90ms over simple detection; response selection (Choice RT) adds another 100–200ms.
- Choice reaction time scales logarithmically with the number of alternatives following Hick's Law (RT = a + b * log2(n+1)).
- Elite athletes and gamers reduce latency by pre-positioning and anticipating, converting 400ms choice tasks into 180ms simple reflexes.

